Fio2 physiologic dead space8/11/2023 FIO2 should be carefully defined for the screening of lung-injured patients. ![]() ![]() P/F variation, induced by a switch from FIO2 0.5 to 1, was responsible for two thirds of patients changing from the acute respiratory distress syndrome to the acute lung injury stage of the American-European Consensus Conference definition. C c O 2 Pulmonary end-capillary oxygen content, assumed to have an oxygen tension equal to PAO 2 (with the corresponding oxygen saturation) C a O 2 Arterial oxygen content. The P/F ratio increased significantly with a FIO2 >0.7. Is expressed as a ratio, or shunt fraction: Q S Q T C c O 2 C a O 2 C c O 2 C v O 2, where: Q S Shunt blood flow. Increasing FIO2 above 0.7 was associated with a significant increase in P/F (p 200 at FIO2 1 whereas P/F was 30% (20% p = 0.003). The following FIO2 levels were applied randomly for 20 mins: 0.5, 0.6, 0.7, 0.8, 0.9, and 1. ![]() Twenty-four patients with acute respiratory distress syndrome having P/F between 100 and 200 mm Hg at FIO2 0.5 received low-volume controlled ventilation (V(T) = 6 mL/kg predicted body weight) with a positive end-expiratory pressure at 2 cm H2O above the lower inflection point if present, or 10 cm H2O. University teaching French medical intensive care unit. Physiological Dead Space ( Total Dead Space ) is the portion of a tidal volume that does not participate in gas exchange because it either remains in the conducting airways (Anatomic Dead Space) or does not get in contact with blood flowing through the pulmonary capillaries (Alveolar Dead Space). Prospective, controlled, interventional study. We investigated the effect of high FIO2 levels on the course of P/F in lung protective mechanically ventilated patients with acute respiratory distress syndrome. ![]() A high FIO2 level has been reported to variably alter PaO2/FIO2. PaO2/FIO2 ratio (P/F) is the marker of hypoxemia used in the American-European Consensus Conference on lung injury. Objective: PaO2/FIO2 ratio (P/F) is the marker of hypoxemia used in the American-European Consensus Conference on lung injury.
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